Contact Dermatitis 2008;59(1):52. Ha Y, Wang T, Li J, et al. J Pharm Pharmacol 2003;55:1275-82. Licorice is an herb that grows in parts of Europe and Asia. Janse A, van Iersel M, Hoefnagels WH, Olde Rikker MG. Reuter, J., Merfort, I., and Schempp, C. M. Botanicals in dermatology: an evidence-based review. The invention belongs to the field of biopesticides, and mainly discloses a nuisanceless biological compound pesticide and a preparation method thereof. Effect of Shakuyaku-kanzo-to (Tsumura TJ-68) on muscle cramps accompanying cirrhosis in a placebo-controlled double-blind parallel study. Taking licorice might reduce the effects of blood pressure medications. mentioned adverse effects and recurrence rates. "It contains liquiritin, an active compound that helps to disperse and remove existing melanin in the skin," explains Chwalek. One of its most known effects is the induction of hypertension, and it can induce what appears to be pseudohyperaldosteronism, due to glycyrrhetinic acid, the main active component of the root. J Agric Food Chem 6-13-2007;55(12):4691-4697. Monograph. Indian J Med Res 1993;98:69-74. View abstract. 1979;14(5):605-607. Another type of licorice, called DGL or deglycyrrhizinated licorice, does not seem to have the same side effects and is sometimes used to treat peptic ulcers, canker sores, and reflux (GERD). How Much Is Too Much? View abstract. Cumming, A. M., Boddy, K., Brown, J. J., Fraser, R., Lever, A. F., Padfield, P. L., and Robertson, J. I. View abstract. A randomized, crossover comparison of herbal medicine and bromocriptine against risperidone-induced hyperprolactinemia in patients with schizophrenia. J Clin Ther Med 1999;15:499-523. Blood Press. J Hum Hypertens 2001;15:549-52. No negative side effects. Eagon PK, Elm MS, Hunter DS, et al. Lee, S. J., Lee, I. S., and Mar, W. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 activity by 1,2,3,4,6-penta-O-galloyl-beta-D-glucose in murine macrophage cells. Qi XG. View abstract. October 15, 2021. Life Sci 1994;55(11):863-872. Chem Pharm Bull (Tokyo) 1994;42(5):1056-1062. [Treatment of refractory polycystic ovary syndrome by bushen huoxue method combined with ultrasound-guided follicle aspiration]. A., van Dokkum, W., and Savelkoul, T. J. Glycyrrhizic acid: the assessment of a no effect level. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. Madisch A, Melderis H, Mayr G, et al. Licorice or Mulethi, also known as "Sweetwood", is an effective and potent medicinal herb. 2020;50:102401. J Hypertens 1985;3(1):19-23. Yamada, K., Kanba, S., Yagi, G., and Asai, M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. Digestion 2004;69:45-52. Brit Med J 1952;1:360-361. Gardner Z, McGuffin M. Boca Raton, FL: CRC Press, 2013. A botanical dietary supplement from white peony and licorice attenuates nonalcoholic fatty liver disease by modulating microbiota and reducing inflammation . J Pharmacobiodyn 1984;7:304-11. Das SK, Das V, Gulati AK, and et al. The effects of dietary licorice flavonoid oil supplementation on body balance control in healthy middle-aged and older Japanese women undergoing a physical exercise intervention: a randomized, double-blind, placebo-controlled trial. View abstract. Epilepsy Res 2021;176:106735. Fang, J. Y. View abstract. Am J Chin Med 1992;20(3-4):313-317. Sigurjonsdottir HA, Franzson L, Manhem K, et al. View abstract. Peters, M. C., Tallman, J. Little is known about whether it's safe to use licorice root while breastfeeding. Isaia, G. C., Pellissetto, C., Ravazzoli, M., and Tamone, C. Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses. Gibertoni, M., Bonito, V., Colombo, A., Falasca, A., and Nichelli, P. [Licorice-induced myopathy. View abstract. Peony and Licorice is a safe and gentle yet powerful formula that is famous for its ability to build blood and balance menstrual cycles. Title 21. Visavadiya, N. P. and Narasimhacharya, A. V. Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (Linn) in rats. Planta Med 2003;69(12):1113-1118. In my research, I found that like with any natural. Tooth decay. View abstract. Guo TL, Zhou XW. Bardhan, K. D., Cumberland, D. C., Dixon, R. A., and Holdsworth, C. D. Clinical trial of deglycyrrhizinised liquorice in gastric ulcer. Astragalus may be safe when used orally and appropriately. Therapeutic Research Faculty 2020. View abstract. Pak J Med Sci 2022;38(1):271-275. Ou TT, Wu CH, Hsu JD, et al. Black licorice can have serious side effects when eaten in large amounts. Benge E, Shah P, Yamaguchi L, Josef V. Trick or Treat? The herb licorice may lower warfarin levels and can add to digoxin's effects. Peony (Paeonia spp). View abstract. Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG. View abstract. But the potential side effects are real enough. Effect of Japanese Angelica root and peony root on uterine contraction in the rabbit in situ. View abstract. View abstract. According to research, the combination of . Fujisawa, Y., Sakamoto, M., Matsushita, M., Fujita, T., and Nishioka, K. Glycyrrhizin inhibits the lytic pathway of complement--possible mechanism of its anti-inflammatory effect on liver cells in viral hepatitis. Yang F, Qi X, Du Y, et al. View abstract. Front Psychiatry 2020;11:605949. 2010;33(2):321-324. View abstract. Isr J Dent Sci 1989;2(3):153-157. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. View abstract. View abstract. Nippon Rinsho 1994;52:1817-22. Meng Xiangrui is an academic researcher. Medicine (Baltimore) 2018;97(11):e0073. Ann Clin Biochem 2007;44(Pt 4):397-399. Prevention of maternal-fetal blood group incompatibility with traditional Chinese herbal medicine. View abstract. . Chamberlain, J. J. and Abolnik, I. Wang H, Wei W, Wang NP, et al. PC-SPES, a dietary supplement for the treatment of hormone-refractory prostate cancer. Arch Pharm Res 2003;26(10):832-839. View abstract. Zhong Xi Yi Jie He Za Zhi 1991;11(3):150-2, 133. View abstract. View abstract. 4-14-2001;145(15):744-747. Thom E and Wollan T. A controlled clinical study of kanjang mixture in the treatment of uncomplicated upper respiratory tract infections. View abstract. . View abstract. and its bioactive compounds. Muscle cramps.Early research suggests that taking a specific combination of peony and licorice (Shakuyaku-kanzoh-to) might ease muscle cramps in people with liver cirrhosis and in people undergoing hemodialysis. Licorice is Sita (cold) in nature, Guru (heavy) to digest, and Madhura (sweet) in . The author has an hindex of 4, co-authored 18 publication(s) receiving 46 citation(s). Licorice, tobacco chewing, and hypertension. Akamatsu, H., Komura, J., Asada, Y., and Niwa, Y. J Infect.Chemother. Exp Ther Med 2016;11(3):1135-41. Xu, L., Jiang, J., and Du, F. Z. van den Bosch AE, van der Klooster JM, Zuidgeest DM, et al. Diane Calello, executive medical director of the New Jersey Poison Control Center, based at Rutgers New Jersey Medical School, discusses safe . The sweet stuff in your kids' trick-or-treat buckets may come with a bitter side effect. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. View abstract. Monitor your blood pressure closely. 2004;4(3):377-386. typica. Kim, H. J., Chang, E. J., Bae, S. J., Shim, S. M., Park, H. D., Rhee, C. H., Park, J. H., and Choi, S. W. Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora. View abstract. Lancet 2003;361:2045-6.. View abstract. View abstract. View abstract. Br Med J 1971;3(773):501-503. Motherwort, Peony, Dong Quai, Lady's Mantle, Licorice, and Rose, Fennel, Alfalfa. Werner, S., Brismar, K., and Olsson, S. Hyperprolactinaemia and liquorice. Jin, C. Y., Wang, D. L., and Fang, Z. D. [Effect of integrative Chinese and Western medicine in treating chronic urticaria and its impact on interleukin-10 and interleukin-8 in peripheral blood]. Drugs & Vitamins . Nishioka, K. and Seguchi, T. Contact allergy due to oil-soluble licorice extracts in cosmetic products. Cancer Lett. Hsu, Y. L., Wu, L. Y., Hou, M. F., Tsai, E. M., Lee, J. N., Liang, H. L., Jong, Y. J., Hung, C. H., and Kuo, P. L. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. View abstract. Z., Zhang, Y. Arch.Pharm Res 2012;35(11):1945-1952. Exp.Mol.Med 12-31-2003;35(6):467-474. Bannister, B., Ginsburg, R., and Shneerson, J. Cardiac arrest due to liquoriceinduced hypokalaemia. Caubet-Kamar, N., Tubery, M., Garrouste, C., Lauque, D., and Kamar, N. Harmful effect of saline infusion in a patient with glycyrrhizic acid poisoning. Kondo K1, Shiba M, Nakamura R, Morota T, Shoyama Y. Eur J Clin Pharmacol 2010;66(8):805-810. Int J Environ Res Public Health 2021;19(1):242. View abstract. View abstract. Li C, Wang ZB. American Herbal Products Association's Botanical Safety Handbook, Second Edition. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11. Attou R, Redant S, Honore PM, Preseau T, Hantson P, De Bels D. Liquorice intoxication can lead to cardiac arrest! View abstract. Gupta D, Agrawal S, Sharma JP. View abstract. Licorice extract inhibits the production of tyrosinase, in turn inhibiting the production of dark spots. Doeker, B. M. and Andler, W. Liquorice, growth retardation and Addison's disease. Neth J Med 2005;63:146-8. Madisch A, Holtmann G, Mayr G, et al. View abstract. J Hum Hypertens 1995;9:345-8. 2011;25(1-2):21-38. Gut 1969;10:299-302. View abstract. Bai, Y. S., Zhou, C. Y., and Wang, J. Q. Jan. 13, 2020 Foods such as honey, licorice, oregano, and hot sauce have an antimicrobial effect and some of them trigger phage production in our gut. Asia Pac.J Clin Nutr 2008;17(1):17-22. 1987;(10):46-48. Patients received either bromocriptine 5 mg daily for 4 weeks followed by 4 weeks of 22.5 grams daily of the peony-licorice decoction (equivalent to 25 mg of glycyrrhetinic acid), or the same drugs in the reverse order. Because licorice has a hormone-like effect, it can relieve excessive gastric acid secretion. View abstract. Phytother Res. Menopause 2002;9:145-50. Lancet 2-10-1973;1(7798):294-295. Early evidence suggests that taking 45 grams of a specific product containing peony and licorice (Peony-Glycyrrhiza Decoction, PGD) daily for 4 weeks reduces levels of a hormone called prolactin in women with high levels of prolactin, without affecting other hormone levels or mental symptoms. 2017 Sep;31(9):1330-1340. Apparent mineralcorticoid excess syndrome, an often forgotten or unrecognized cause of hypokalemia and hypertension: case report and appraisal of the pathophysiology. A Rutgers expert discusses how eating black licorice can affect your health. O'Connell, R. L., White, I. R., White, J. M., and McFadden, J. P. Liquorice extract in a cosmetic product causing contact allergy. Other conditions. Lee, C. K., Park, K. K., Lim, S. S., Park, J. H., and Chung, W. Y. People who regularly take large amounts of licorice, more than 20 g/day, may raise blood levels of the hormone aldosterone, which can cause serious side effects, including headache, high blood pressure, and heart problems. Sheehan MP, Atherton DJ. Some possible side effects with oral use include rash, itching, nasal symptoms, or stomach discomfort, but these are uncommon. Da Nagao, Y., Sata, M., Suzuki, H., Tanikawa, K., Itoh, K., and Kameyama, T. Effectiveness of glycyrrhizin for oral lichen planus in patients with chronic HCV infection. View abstract. Zhong Xi Yi Jie He Za Zhi 1991;11:102-4, 69. Total glucosides of peony ameliorates Sjogren's syndrome by affecting Th1/Th2 cytokine balance. View abstract. and Glycyrrhiza glabra L. extracts in patients with Familial Mediterranean Fever. Arch Pharm Res 2002;25(3):293-299. Paeonia lactiflora (Chinese peony) and Paeonia brownii (California peony) relax smooth muscle tissue with a particular affinity for the female reproductive tract. View abstract. View abstract. Most clinical trials have found that when Peony is combined with Licorice Rt. Engqvist, A., von Feilitzen, F., Pyk, E., and Reichard, H. Double-blind trial of deglycyrrhizinated liquorice in gastric ulcer. Some medications are changed and broken down by the liver. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Researchers from the University of Minnesota studied 50 atopic dogs in a randomized, double-blind, placebo-controlled trial. J Agric Food Chem 2012;60(36):9062-73. Antiviral Res 1989;11(5-6):255-261. In 1977, researchers reported the case of a 58-year-old woman who was eating a whopping 1.8 kilograms (about 63.5 ounces) of black licorice per week and went into cardiac arrest. The efficacy and safety of the combination of total glucosides of peony and leflunomide for the treatment of rheumatoid arthritis: a systematic review and meta-analysis. Strandberg TE, Andersson S, Jarvenpaa AL, et al. de Klerk GJ, Nieuwenhuis G, Beutler JJ. [Peony tincture in the complex treatment of allergic dermatoses]. Crit Care 2011;15(1):R64. Yuan, H. N., Wang, C. Y., Sze, C. W., Tong, Y., Tan, Q. R., Feng, X. J., Liu, R. M., Zhang, J. Dellow EL, Unwin RJ, Honour JW. Grapefruit juice and its flavonoids inhibit 11 beta-hydroxysteroid dehydrogenase. View abstract. N Engl J Med. Xu Y, Li X, Chen T, et al. J Steroid Biochem Mol Biol 1994;49:81-5. . Zheng, A. and Moritani, T. Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity and immune system under mental arithmetic stress. Ann Noninvasive Electrocardiol. Br J Clin Pharmacol 2008;66:572-4. Costa, A., Moises, T. A., Cordero, T., Alves, C. R., and Marmirori, J. View abstract. Ruiz-Granados, E. S., Shouls, G., Sainsbury, C., and Antonios, T. A salty cause of severe hypertension. Clinical application of compound Glycyrrhizin tablets in the treatment of patients with Simplex Henoch-Schonlein Purpura and its effect on immune function. Edelman ER, Butala NM, Avery LL, Lundquist AL, Dighe AS. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Hypertension encephalopathy after liquorice ingestion. Bernardi, M., D'Intino, P. E., Trevisani, F., Cantelli-Forti, G., Raggi, M. A., Turchetto, E., and Gasbarrini, G. Effects of prolonged ingestion of graded doses of licorice by healthy volunteers. Lozenge-induced hypermineralcorticoid state--a unique case of licorice lozenges resulting in hypertension and hypokalemia. Biol Pharm Bull 1998;21:1277-81. Armanini D, Lewicka S, Pratesi C, et al. Eur J Pharmacol 11-7-2005;524(1-3):111-119. Riv Patol Nerv Ment 1983;104(4):179-183. BJU Int 2000;85:481-5. View abstract. Bell ZW, Canale RE, Bloomer RJ. Gulf J Oncolog 2021;1(37):42-47. BMJ 1997;314:731-2. Rackova, L., Jancinova, V., Petrikova, M., Drabikova, K., Nosal, R., Stefek, M., Kostalova, D., Pronayova, N., and Kovacova, M. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin. Neth J Med 2005;63:149-50. Am J Chin Med 2005;33(5):747-758. Huang, W. W., Wang, M. Y., Shi, H. M., Peng, Y., Peng, C. S., Zhang, M., Li, Y., Lu, J., and Li, X. Zhu Q, Qi X, Wu Y, Wang K. Clinical study of total glucosides of paeony for the treatment of diabetic kidney disease in patients with diabetes mellitus. Licorice that has the active ingredient of glycyrrhiza can have serious side effects. [Effectiveness of interferon, glycyrrhizin combination therapy in patients with chronic hepatitis C]. Asian Medical Journal 1984;26(7):423-438. Although white peony is generally considered safe for most people, drinking large amounts might have some negative consequences. But not everyone will have the side . Read more. Overview. Guo, D., Ye, G., and Guo, H. A new phenolic glycoside from Paeonia lactiflora. Kumada T, et al. Am J Clin Dermatol 2010;11(4):247-267. View abstract. View abstract. Eur.Arch.Paediatr.Dent 2010;11(6):274-278. View abstract. 1994;14:207-9, 195. . Therapeutic Research Faculty 2020. View abstract. Roussak NJ. Antiviral Res 1987;7(2):99-107. 2003;23(8):593-595. West J Med 1997;167(3):184-185. Platelet anti-aggregatory and blood anti-coagulant effects of compounds isolated from Paeonia lactiflora and Paeonia suffruticosa. Licorice is believed to have anti-androgenic effects, meaning that it may be active to reduce testosterone levels. This could change the effects and side effects of these medications. J Contemp.Dent Pract. Schweiz Med Wochenschr 2-26-1977;107(8):276-279. View abstract. Note: Results may vary from person to person, depending on the skin type. Mu Y, Zhang J, Zhang S, et al. View abstract. Licorice seems to change hormone levels in the body. Kinoshita T, Maruyama K, Yamamoto N, Saito I. 2018;38(2):617-8. Taking licorice with paclitaxel might decrease the effects of paclitaxel. View abstract. Klin Wochenschr 1983;61:303-5. Growth-inhibiting, bactericidal, and urease inhibitory effects of Paeonia lactiflora root constituents and related compounds on antibiotic-susceptible and -resistant strains of Helicobacter pylori. View abstract. Awad N, Makar G, Burroughs V, Ravi P, Burroughs SR. Licorice-induced apparent mineralocorticoid excess causing persistent hypertension and hypokalemia. View abstract. Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Res 1996;30:171-7. Lipids Health Dis 2011;10:29. [Effect of dandi tablet on blood lipids and sex hormones in women of postmenopausal stage]. Kitagawa, I., Chen, W. Z., Hori, K., Harada, E., Yasuda, N., Yoshikawa, M., and Ren, J. View abstract. Saw palmetto. Yasue H, Itoh T, Mizuno Y, Harada E. Severe hypokalemia, rhabdomyolysis, muscle paralysis, and respiratory impairment in a hypertensive patient taking herbal medicines containing licorice.